Motif ID: HOX{A4,D4}.p2

Z-value: 0.568


Transcription factors associated with HOX{A4,D4}.p2:

Gene SymbolEntrez IDGene Name
HOXA4 3201 homeobox A4
HOXD4 3233 homeobox D4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXD4chr2_+_1770161120.521.9e-01Click!
HOXA4chr7_-_27170351-0.059.1e-01Click!


Activity profile for motif HOX{A4,D4}.p2.

activity profile for motif HOX{A4,D4}.p2


Sorted Z-values histogram for motif HOX{A4,D4}.p2

Sorted Z-values for motif HOX{A4,D4}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A4,D4}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_100199881 0.478 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr6_+_132891460 0.459 NM_175067
TAAR6
trace amine associated receptor 6
chr3_+_45067750 0.414 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chr2_-_163099877 0.365 NM_004460
FAP
fibroblast activation protein, alpha
chr10_-_92681025 0.327 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr9_+_127420690 0.327 MIR181A2HG
MIR181A2 host gene (non-protein coding)
chr1_+_160160284 0.311 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr12_-_10588543 0.310 NM_002260
KLRC2
KLRC3
killer cell lectin-like receptor subfamily C, member 2
killer cell lectin-like receptor subfamily C, member 3
chr8_-_122653493 0.299 NM_005328
HAS2
hyaluronan synthase 2
chr13_+_102104941 0.298 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr2_+_177016112 0.291 NM_014621
HOXD4
homeobox D4
chr4_+_70916158 0.263 NM_002159
HTN1
histatin 1
chr12_+_60083125 0.262 NM_004731
SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr10_+_99498233 0.260 NM_001002261
ZFYVE27
zinc finger, FYVE domain containing 27
chr17_+_48821106 0.254 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr3_+_180320955 0.253 TTC14
tetratricopeptide repeat domain 14
chr7_-_138363789 0.251 NM_001139456
SVOPL
SVOP-like
chr2_+_128175989 0.243 NM_000312
PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr2_+_189839078 0.242 NM_000090
COL3A1
collagen, type III, alpha 1
chr1_+_201708648 0.238 NAV1
neuron navigator 1
chr15_-_40630272 0.237 C15orf52
chromosome 15 open reading frame 52
chr17_-_64225496 0.233 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr12_+_1726221 0.226 NM_030775
WNT5B
wingless-type MMTV integration site family, member 5B
chrX_+_103031797 0.223 PLP1
proteolipid protein 1
chr18_-_65182507 0.218 DSEL
dermatan sulfate epimerase-like
chr14_+_51026853 0.217 ATL1
atlastin GTPase 1
chr14_+_51026742 0.216 NM_015915
NM_181598
ATL1

atlastin GTPase 1

chr1_+_45274153 0.215 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr10_-_70066594 0.214 PBLD
phenazine biosynthesis-like protein domain containing
chr5_+_69696805 0.212 SMA4
glucuronidase, beta pseudogene
chr4_+_74606222 0.208 NM_000584
IL8
interleukin 8
chr3_-_112358510 0.200 CCDC80
coiled-coil domain containing 80
chr9_+_120466625 0.197 TLR4
toll-like receptor 4
chr8_-_25282555 0.197 NM_000825
NM_001083111
GNRH1

gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)

chrX_+_79675945 0.195 NM_152630
FAM46D
family with sequence similarity 46, member D
chr1_-_144997110 0.195 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr2_-_188419049 0.194 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr2_+_177016337 0.191


chr14_-_38064176 0.190 FOXA1
forkhead box A1
chr1_-_12891262 0.190 NM_001146344
PRAMEF11
PRAME family member 11
chr6_-_31514620 0.187 NM_001204078
NM_130463
NM_138282
ATP6V1G2


ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2


chr13_-_33780142 0.187 NM_001243474
NM_052851
STARD13

StAR-related lipid transfer (START) domain containing 13

chr20_+_43029973 0.186 HNF4A
hepatocyte nuclear factor 4, alpha
chr3_-_112359547 0.185 CCDC80
coiled-coil domain containing 80
chr10_-_33623299 0.183 NRP1
neuropilin 1
chr7_-_107880492 0.182 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr5_+_149569519 0.181 NM_014228
SLC6A7
solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
chr8_-_13372183 0.180 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chr3_-_69037498 0.180 C3orf64
chromosome 3 open reading frame 64
chr22_+_22735202 0.180


chr3_+_11294384 0.179 NM_000861
HRH1
histamine receptor H1
chr6_-_31514393 0.179 ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr11_+_113775517 0.178 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr14_-_38064440 0.177 NM_004496
FOXA1
forkhead box A1
chr3_-_112359565 0.177 CCDC80
coiled-coil domain containing 80
chr15_+_89631625 0.176 ABHD2
abhydrolase domain containing 2
chr3_+_186560462 0.174 NM_001177800
NM_004797
ADIPOQ

adiponectin, C1Q and collagen domain containing

chr18_+_61144143 0.174 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr10_+_69869249 0.173 NM_032578
MYPN
myopalladin
chr3_+_186560478 0.172 ADIPOQ
adiponectin, C1Q and collagen domain containing
chr10_-_44063906 0.172 NM_005674
ZNF239
zinc finger protein 239
chr15_+_89631731 0.171 ABHD2
abhydrolase domain containing 2
chr5_+_140571903 0.170 NM_018930
PCDHB10
protocadherin beta 10
chr6_+_72892371 0.170 RIMS1
regulating synaptic membrane exocytosis 1
chr20_+_44518782 0.169 CTSA
cathepsin A
chr10_+_91061705 0.169 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chrX_+_103031753 0.166 NM_000533
NM_199478
PLP1

proteolipid protein 1

chr2_-_188419185 0.165 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chrX_+_103031433 0.164 NM_001128834
PLP1
proteolipid protein 1
chr4_+_71200670 0.163 NM_033122
CABS1
calcium-binding protein, spermatid-specific 1
chr3_-_112359251 0.159 CCDC80
coiled-coil domain containing 80
chr2_+_189839113 0.158 COL3A1
collagen, type III, alpha 1
chr5_+_140810181 0.156 PCDHGA12
protocadherin gamma subfamily A, 12
chr6_-_46293628 0.156 NM_005822
RCAN2
regulator of calcineurin 2
chr16_-_87970107 0.155 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr1_-_12677347 0.154 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr4_+_88754120 0.154 NM_001184695
NM_001184696
NM_001184697
NM_020203
MEPE



matrix extracellular phosphoglycoprotein



chr5_+_140474198 0.154 NM_018936
PCDHB2
protocadherin beta 2
chr15_+_89631695 0.154 ABHD2
abhydrolase domain containing 2
chr1_-_151431648 0.153 POGZ
pogo transposable element with ZNF domain
chr7_+_116660263 0.153 ST7
suppression of tumorigenicity 7
chr15_+_89739234 0.153 ABHD2
abhydrolase domain containing 2
chr5_+_147582338 0.153 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr5_+_71403040 0.152 NM_005909
MAP1B
microtubule-associated protein 1B
chr4_+_41614725 0.150 LIMCH1
LIM and calponin homology domains 1
chr2_+_152214105 0.150 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr5_+_140739589 0.148 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr2_-_211179765 0.148 NM_079420
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr7_-_75443026 0.147 NM_002991
CCL24
chemokine (C-C motif) ligand 24
chr8_-_72268720 0.147 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr12_-_29937691 0.145 NM_175861
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr3_-_112359277 0.145 CCDC80
coiled-coil domain containing 80
chr3_-_114866090 0.144 NM_015642
ZBTB20
zinc finger and BTB domain containing 20
chr9_+_97521930 0.143 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr7_+_100770378 0.143 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr15_-_37391893 0.142 MEIS2
Meis homeobox 2
chr16_+_4421774 0.142 NM_138440
VASN
vasorin
chr5_+_140868721 0.141 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr12_-_4754275 0.141 NM_006422
AKAP3
A kinase (PRKA) anchor protein 3
chr5_+_140810126 0.141 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr7_-_92747269 0.140 SAMD9
sterile alpha motif domain containing 9
chr17_+_53344966 0.140 HLF
hepatic leukemia factor
chr18_+_3247825 0.139 MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr7_+_116660291 0.139 ST7
suppression of tumorigenicity 7
chr1_+_104097321 0.138 NM_020978
AMY2B
amylase, alpha 2B (pancreatic)
chr5_-_96149804 0.137 NM_001198541
ERAP1
endoplasmic reticulum aminopeptidase 1
chr7_+_2557496 0.136 NM_002304
LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr14_+_64680858 0.135 NM_182913
SYNE2
spectrin repeat containing, nuclear envelope 2
chr2_-_32490688 0.134 NM_001199139
NM_021209
NLRC4

NLR family, CARD domain containing 4

chr12_+_75874512 0.132 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr5_+_140810326 0.131 PCDHGA12
protocadherin gamma subfamily A, 12
chr12_+_41831484 0.131 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr5_+_67586466 0.130 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr6_+_47624222 0.130 NM_153839
GPR111
G protein-coupled receptor 111
chr2_+_128176019 0.129 PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr17_-_39092714 0.129 KRT23
keratin 23 (histone deacetylase inducible)
chr10_-_92680784 0.129 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr8_-_108510094 0.128 NM_001146
NM_001199859
ANGPT1

angiopoietin 1

chr12_-_95467104 0.128 NM_001032287
NM_001127362
NM_003297
NR2C1


nuclear receptor subfamily 2, group C, member 1


chr1_+_150245182 0.128 NM_024579
C1orf54
chromosome 1 open reading frame 54
chr17_+_7384720 0.127 NM_001102614
SLC35G6
solute carrier family 35, member G6
chr17_-_53809444 0.127 NM_001099640
TMEM100
transmembrane protein 100
chr7_+_141811508 0.126 LOC93432
maltase-glucoamylase (alpha-glucosidase) pseudogene
chr1_+_215178884 0.125 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr3_+_108541544 0.125 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr3_-_52737599 0.124 NM_152932
GLT8D1
glycosyltransferase 8 domain containing 1
chr17_-_67138013 0.123 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr8_+_38831667 0.122 NM_153692
HTRA4
HtrA serine peptidase 4
chr3_+_46619075 0.122 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr3_-_178984789 0.122 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr16_+_55515468 0.121 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr7_+_23286384 0.119 GPNMB
glycoprotein (transmembrane) nmb
chr1_+_161676761 0.119 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr9_-_8733893 0.119 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr8_+_1952875 0.119 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr2_+_189839132 0.118 COL3A1
collagen, type III, alpha 1
chr17_-_38911524 0.118 NM_181534
KRT25
keratin 25
chr1_+_201709051 0.117 NAV1
neuron navigator 1
chr6_+_29274402 0.116 NM_030946
OR14J1
olfactory receptor, family 14, subfamily J, member 1
chr3_-_74570262 0.116 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr19_-_12845539 0.115 C19orf43
chromosome 19 open reading frame 43
chr3_+_130569368 0.115 NM_001199180
NM_001199181
NM_001199182
ATP2C1


ATPase, Ca++ transporting, type 2C, member 1


chr10_-_69455926 0.114 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr17_-_38721701 0.114 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chrX_+_144902865 0.114 NM_001144006
NM_001144008
NM_001144009
NM_001144010
SLITRK2



SLIT and NTRK-like family, member 2



chrY_-_19882311 0.113 NM_001002906
NM_004677
XKRY2
XKRY
XK, Kell blood group complex subunit-related, Y-linked 2
XK, Kell blood group complex subunit-related, Y-linked
chr14_+_21756135 0.113 NM_020366
RPGRIP1
retinitis pigmentosa GTPase regulator interacting protein 1
chr5_-_138210992 0.113 CTNNA1
LRRTM2
catenin (cadherin-associated protein), alpha 1, 102kDa
leucine rich repeat transmembrane neuronal 2
chrX_-_112066353 0.112 NM_001113490
AMOT
angiomotin
chr12_-_10605928 0.111 NM_002259
NM_007328
KLRC1

killer cell lectin-like receptor subfamily C, member 1

chr20_-_4990913 0.111 NM_203327
SLC23A2
solute carrier family 23 (nucleobase transporters), member 2
chr4_-_41750936 0.111 NM_003924
PHOX2B
paired-like homeobox 2b
chr1_+_40735749 0.110 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chrM_+_4465 0.109


chrM_+_6138 0.109


chr4_-_156787377 0.108 NM_017419
ACCN5
amiloride-sensitive cation channel 5, intestinal
chr22_+_31366662 0.108


chr3_+_73110809 0.108 NM_018029
EBLN2
endogenous Bornavirus-like nucleoprotein 2
chr3_-_18480203 0.107 NM_001131010
SATB1
SATB homeobox 1
chr3_+_69134057 0.107 NM_006407
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr5_+_126988706 0.106 NM_001127385
CTXN3
cortexin 3
chr2_-_96482382 0.106 LINC00342
long intergenic non-protein coding RNA 342
chr20_-_17641122 0.105 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chr17_-_79269082 0.104 NM_001037984
NM_138570
SLC38A10

solute carrier family 38, member 10

chr9_-_27005649 0.104 NM_022901
LRRC19
leucine rich repeat containing 19
chr3_-_48601200 0.103 NM_033199
UCN2
urocortin 2
chr8_-_139926235 0.103 NM_152888
COL22A1
collagen, type XXII, alpha 1
chrX_+_16964730 0.103 NM_001080975
NM_004726
REPS2

RALBP1 associated Eps domain containing 2

chr7_+_23286390 0.102 GPNMB
glycoprotein (transmembrane) nmb
chr5_+_156696351 0.102 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr11_-_71752099 0.102 NUMA1
nuclear mitotic apparatus protein 1
chr3_-_114343052 0.101 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr9_+_72658735 0.100 MAMDC2
MAM domain containing 2
chr7_-_126883568 0.100 NM_000845
GRM8
glutamate receptor, metabotropic 8
chr17_+_3379295 0.100 NM_000049
ASPA
aspartoacylase
chr3_-_47933997 0.098 MAP4
microtubule-associated protein 4
chr12_+_15699277 0.098 NM_030668
NM_030669
NM_030670
NM_030671
PTPRO



protein tyrosine phosphatase, receptor type, O



chr11_-_94134575 0.098 NM_016540
GPR83
G protein-coupled receptor 83
chr2_+_87144737 0.098 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr20_+_61476475 0.098 NM_080750
DPH3P1
DPH3, KTI11 homolog (S. cerevisiae) pseudogene 1
chr5_+_140430960 0.097 NM_013340
PCDHB1
protocadherin beta 1
chr1_+_174843523 0.097 NM_001243763
RABGAP1L
RAB GTPase activating protein 1-like
chrX_+_99899162 0.096 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr5_-_138211054 0.096 NM_015564
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr19_+_4153593 0.096 NM_032607
CREB3L3
cAMP responsive element binding protein 3-like 3
chr11_+_22688156 0.096 NM_001143830
GAS2
growth arrest-specific 2
chr3_+_97868169 0.096 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr16_+_31366468 0.095 NM_000887
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr12_+_56522049 0.095 ESYT1
extended synaptotagmin-like protein 1
chr3_-_114102488 0.095 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr16_-_73092533 0.095 NM_001164766
ZFHX3
zinc finger homeobox 3
chr17_-_39538635 0.094 NM_021013
KRT34
keratin 34
chr17_+_30677187 0.094 ZNF207
zinc finger protein 207
chr16_+_24740945 0.094 NM_014494
TNRC6A
trinucleotide repeat containing 6A
chr13_-_24007822 0.093 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr22_+_39353526 0.093 NM_001193289
NM_145699
APOBEC3A

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A

chr2_+_183582667 0.093 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr13_+_78109808 0.093 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr12_+_56522043 0.092 ESYT1
extended synaptotagmin-like protein 1
chr5_-_41510627 0.092 NM_001005473
PLCXD3
phosphatidylinositol-specific phospholipase C, X domain containing 3

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.55 2.11e-05 GO:0044421 extracellular region part
1.62 5.27e-05 GO:0005615 extracellular space
1.30 2.69e-03 GO:0005576 extracellular region
1.38 2.60e-02 GO:0005783 endoplasmic reticulum
1.14 3.46e-02 GO:0031224 intrinsic to membrane
1.14 4.72e-02 GO:0016021 integral to membrane

Nothing significant found in function category.